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Research Article

Integrative Approach to Pain Genetics Identifies Pain Sensitivity Loci across Diseases

  • David Ruau mail,

    druau@stanford.edu

    Affiliations: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America, Division of System Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America, Department of Anesthesia and Pain Management, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America

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  • Joel T. Dudley,

    Affiliation: Division of System Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Rong Chen,

    Affiliation: Division of System Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

    Current address: Personalis, Inc., Palo Alto, California, United States of America.

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  • Nicholas G. Phillips,

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Gary E. Swan,

    Affiliation: Center for Health Sciences, SRI International, Menlo Park, California, United States of America

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  • Laura C. Lazzeroni,

    Affiliation: Departments of Psychiatry and Behavioral Sciences and of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

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  • J. David Clark,

    Affiliations: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America, Department of Anesthesia and Pain Management, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America

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  • Atul J. Butte equal contributor,

    equal contributor Contributed equally to this work with: Atul J. Butte, Martin S. Angst

    Affiliation: Division of System Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Martin S. Angst equal contributor

    equal contributor Contributed equally to this work with: Atul J. Butte, Martin S. Angst

    Affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: June 07, 2012
  • DOI: 10.1371/journal.pcbi.1002538

About the Authors

David Ruau, Nicholas G. Phillips, J. David Clark, Martin S. Angst
Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
David Ruau, Joel T. Dudley, Rong Chen, Atul J. Butte
Division of System Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
David Ruau, J. David Clark
Department of Anesthesia and Pain Management, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
Gary E. Swan
Center for Health Sciences, SRI International, Menlo Park, California, United States of America
Laura C. Lazzeroni
Departments of Psychiatry and Behavioral Sciences and of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: druau@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DR LCL JDC AJB MSA. Performed the experiments: DR JTD RC NGP. Analyzed the data: DR. Contributed reagents/materials/analysis tools: GES. Wrote the paper: DR AJB MSA.