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Research Article

The CanOE Strategy: Integrating Genomic and Metabolic Contexts across Multiple Prokaryote Genomes to Find Candidate Genes for Orphan Enzymes

  • Adam Alexander Thil Smith mail,

    aatsmith@orange.fr (AATS); vallenet@genoscope.cns.fr (DV)

    Affiliations: CEA, DSV, IG, Genoscope, Evry, France, CNRS-UMR8030, Evry, France, Université d'Evry Val d'Essonne, Evry, France

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  • Eugeni Belda,

    Affiliations: CEA, DSV, IG, Genoscope, Evry, France, CNRS-UMR8030, Evry, France, Université d'Evry Val d'Essonne, Evry, France

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  • Alain Viari,

    Affiliation: INRIA Grenoble-Rhône-Alpes, Team BAMBOO, Montbonnot, France

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  • Claudine Medigue,

    Affiliations: CEA, DSV, IG, Genoscope, Evry, France, CNRS-UMR8030, Evry, France, Université d'Evry Val d'Essonne, Evry, France

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  • David Vallenet mail

    aatsmith@orange.fr (AATS); vallenet@genoscope.cns.fr (DV)

    Affiliations: CEA, DSV, IG, Genoscope, Evry, France, CNRS-UMR8030, Evry, France, Université d'Evry Val d'Essonne, Evry, France

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  • Published: May 31, 2012
  • DOI: 10.1371/journal.pcbi.1002540

About the Authors

Adam Alexander Thil Smith, Eugeni Belda, Claudine Medigue, David Vallenet
CEA, DSV, IG, Genoscope, Evry, France
Adam Alexander Thil Smith, Eugeni Belda, Claudine Medigue, David Vallenet
CNRS-UMR8030, Evry, France
Adam Alexander Thil Smith, Eugeni Belda, Claudine Medigue, David Vallenet
Université d'Evry Val d'Essonne, Evry, France
Alain Viari
INRIA Grenoble-Rhône-Alpes, Team BAMBOO, Montbonnot, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AATS DV. Performed the experiments: AATS. Analyzed the data: AATS EB DV. Contributed reagents/materials/analysis tools: AV DV. Wrote the paper: AATS DV. Reviewed the manuscript: AV CM. Carried out bioanalysis: EB DV.