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Research Article

Complex Spatial Dynamics of Oncolytic Viruses In Vitro: Mathematical and Experimental Approaches

  • Dominik Wodarz mail,

    dwodarz@uci.edu

    Affiliations: Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America, Department of Mathematics, Rowland Hall, University of California, Irvine, California, United States of America

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  • Andrew Hofacre,

    Affiliation: Department of Molecular Biology and Biochemistry, Cancer Research Institute, University of California Irvine, California, United States of America

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  • John W. Lau,

    Affiliation: Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America

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  • Zhiying Sun,

    Affiliations: Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America, Department of Mathematics, Rowland Hall, University of California, Irvine, California, United States of America

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  • Hung Fan,

    Affiliation: Department of Molecular Biology and Biochemistry, Cancer Research Institute, University of California Irvine, California, United States of America

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  • Natalia L. Komarova

    Affiliations: Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America, Department of Mathematics, Rowland Hall, University of California, Irvine, California, United States of America

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.pcbi.1002547

About the Authors

Dominik Wodarz, John W. Lau, Zhiying Sun, Natalia L. Komarova
Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America
Dominik Wodarz, Zhiying Sun, Natalia L. Komarova
Department of Mathematics, Rowland Hall, University of California, Irvine, California, United States of America
Andrew Hofacre, Hung Fan
Department of Molecular Biology and Biochemistry, Cancer Research Institute, University of California Irvine, California, United States of America

Corresponding Author

Email: dwodarz@uci.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DW HF NLK. Performed the experiments: DW AH JWL ZS NLK. Analyzed the data: DW AH HF NLK. Contributed reagents/materials/analysis tools: DW AH HF NLK. Wrote the paper: DW NLK.