A Scalable Algorithm to Explore the Gibbs Energy Landscape of Genome-Scale Metabolic Networks

Daniele De Martino; Matteo Figliuzzi; Andrea De Martino; Enzo Marinari

doi:10.1371/journal.pcbi.1002562

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Open Access

Peer-reviewed

Research Article

A Scalable Algorithm to Explore the Gibbs Energy Landscape of Genome-Scale Metabolic Networks

Daniele De Martino,

Affiliation Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy
⨯
Matteo Figliuzzi,

Affiliation Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy
⨯
Andrea De Martino ,

Contributed equally to this work with: Andrea De Martino, Enzo Marinari

Affiliations Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy, CNR-IPCF, Unità di Roma-Sapienza, Roma, Italy
⨯
Enzo Marinari

Contributed equally to this work with: Andrea De Martino, Enzo Marinari

Affiliation Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy
⨯

A Scalable Algorithm to Explore the Gibbs Energy Landscape of Genome-Scale Metabolic Networks

Daniele De Martino,
Matteo Figliuzzi,
Andrea De Martino,
Enzo Marinari

Published: June 21, 2012
https://doi.org/10.1371/journal.pcbi.1002562

About the Authors

Daniele De Martino

Affiliation Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy

Matteo Figliuzzi

Affiliation Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy

Andrea De Martino

Contributed equally to this work with: Andrea De Martino, Enzo Marinari

Affiliations Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy, CNR-IPCF, Unità di Roma-Sapienza, Roma, Italy

Enzo Marinari

Contributed equally to this work with: Andrea De Martino, Enzo Marinari

Affiliation Dipartimento di Fisica, Sapienza Università di Roma, Roma, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ADM EM. Performed the experiments: DDM MF. Analyzed the data: DDM MF. Contributed reagents/materials/analysis tools: DDM MF ADM EM. Wrote the paper: DDM MF ADM EM.

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Metabolic networks
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Thermodynamics
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Metabolites
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Cell metabolism
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Bioenergetics
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Stoichiometry
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Algorithms
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Genomics
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