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Research Article

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation

  • Crina-Maria Ionescu,

    Affiliations: CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • Radka Svobodová Vařeková,

    Affiliations: CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • Jochen H. M. Prehn,

    Affiliations: Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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  • Heinrich J. Huber,

    Affiliations: Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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  • Jaroslav Koča mail

    jkoca@ceitec.muni.cz

    Affiliations: CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.pcbi.1002565

About the Authors

Crina-Maria Ionescu, Radka Svobodová Vařeková, Jaroslav Koča
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Crina-Maria Ionescu, Radka Svobodová Vařeková, Jaroslav Koča
National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic
Jochen H. M. Prehn, Heinrich J. Huber
Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
Jochen H. M. Prehn, Heinrich J. Huber
Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Corresponding Author

Email: jkoca@ceitec.muni.cz

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RSV HJH JK. Performed the experiments: CMI. Analyzed the data: CMI RSV JHMP HJH JK. Contributed reagents/materials/analysis tools: RSV HJH. Wrote the paper: CMI RSV JHMP HJH JK.