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Research Article

Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology

  • Robert Moss,

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia

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  • Thibault Grosse,

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France

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  • Ivanny Marchant,

    Affiliation: Escuela de Medicina, Departamento de Pre-clínicas, Universidad de Valparaíso, Valparaíso, Chile

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  • Nathalie Lassau,

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France

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  • François Gueyffier,

    Affiliations: IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, INSERM, CIC 201, EPICIME, Lyon, France, Service de Pharmacologie Clinique, Hop L Pradel, Centre Hospitalier Universitaire Lyon, Lyon, France

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  • S. Randall Thomas mail

    srandall.thomas@gmail.com

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France

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  • Published: June 28, 2012
  • DOI: 10.1371/journal.pcbi.1002571

About the Authors

Robert Moss, Thibault Grosse, Nathalie Lassau, S. Randall Thomas
IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France
Robert Moss, Thibault Grosse, Nathalie Lassau, S. Randall Thomas
Institut Gustave Roussy, Villejuif, France
Robert Moss
Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia
Ivanny Marchant
Escuela de Medicina, Departamento de Pre-clínicas, Universidad de Valparaíso, Valparaíso, Chile
François Gueyffier
IMTh – Institute for Theoretical Medicine, Lyon, France
François Gueyffier
Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France
François Gueyffier
INSERM, CIC 201, EPICIME, Lyon, France
François Gueyffier
Service de Pharmacologie Clinique, Hop L Pradel, Centre Hospitalier Universitaire Lyon, Lyon, France

Corresponding Author

Email: srandall.thomas@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RM TG FG SRT. Performed the experiments: RM TG SRT. Analyzed the data: RM TG SRT. Contributed reagents/materials/analysis tools: RM TG NL SRT. Wrote the paper: RM TG IM NL FG SRT.