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Research Article

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

  • Miles Miller equal contributor,

    equal contributor Contributed equally to this work with: Miles Miller, Marc Hafner

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Marc Hafner equal contributor,

    equal contributor Contributed equally to this work with: Miles Miller, Marc Hafner

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, School of Computer and Communication Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Department of Biochemistry, University of Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

    Current address: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Eduardo Sontag,

    Affiliation: Department of Mathematics, Rutgers University, New Brunswick, New Jersey, United States of America

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  • Noah Davidsohn,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Sairam Subramanian,

    Affiliation: Department of Electrical Engineering, Princeton University, Princeton, New Jersey, United States of America

    X
  • Priscilla E. M. Purnick,

    Affiliation: Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Douglas Lauffenburger,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Ron Weiss mail

    rweiss@mit.edu

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: July 19, 2012
  • DOI: 10.1371/journal.pcbi.1002579
  • Featured in PLOS Collections

About the Authors

Miles Miller, Marc Hafner, Noah Davidsohn, Douglas Lauffenburger, Ron Weiss
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Marc Hafner
School of Computer and Communication Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Marc Hafner
Department of Biochemistry, University of Zurich, Zurich, Switzerland
Marc Hafner
Swiss Institute of Bioinformatics, Lausanne, Switzerland
Eduardo Sontag
Department of Mathematics, Rutgers University, New Brunswick, New Jersey, United States of America
Sairam Subramanian
Department of Electrical Engineering, Princeton University, Princeton, New Jersey, United States of America
Priscilla E. M. Purnick
Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: rweiss@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM MH PEMP RW. Performed the experiments: MM MH ND SS. Analyzed the data: MM MH ES RW. Contributed reagents/materials/analysis tools: MM MH ES DL. Wrote the paper: MM MH ES RW.