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Research Article

Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

  • Willem de Haan mail,

    w.dehaan@vumc.nl

    Affiliations: Department of Clinical Neurophysiology and MEG, VU University Medical Center, Amsterdam, The Netherlands, Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands

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  • Katherine Mott,

    Affiliation: Department of Clinical Neurophysiology and MEG, VU University Medical Center, Amsterdam, The Netherlands

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  • Elisabeth C. W. van Straaten,

    Affiliation: Department of Clinical Neurophysiology and MEG, VU University Medical Center, Amsterdam, The Netherlands

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  • Philip Scheltens,

    Affiliation: Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands

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  • Cornelis J. Stam

    Affiliation: Department of Clinical Neurophysiology and MEG, VU University Medical Center, Amsterdam, The Netherlands

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.pcbi.1002582
  • Featured in PLOS Collections

About the Authors

Willem de Haan, Katherine Mott, Elisabeth C. W. van Straaten, Cornelis J. Stam
Department of Clinical Neurophysiology and MEG, VU University Medical Center, Amsterdam, The Netherlands
Willem de Haan, Philip Scheltens
Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands

Corresponding Author

Email: w.dehaan@vumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJS. Performed the experiments: WDH KM. Analyzed the data: WDH KM. Contributed reagents/materials/analysis tools: CJS. Wrote the paper: WDH. Helped drafting the manuscript: KM ECWvS PS CJS.