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Research Article

A Nonlinear Dynamic Approach Reveals a Long-Term Stroke Effect on Cerebral Blood Flow Regulation at Multiple Time Scales

  • Kun Hu mail,

    khu@bics.bwh.harvard.edu (KH); mzlo@ncu.edu.tw (MTL)

    Affiliations: Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan

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  • Men-Tzung Lo mail,

    khu@bics.bwh.harvard.edu (KH); mzlo@ncu.edu.tw (MTL)

    Affiliations: Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan, Division of Interdisciplinary Medicine & Biotechnology and Margret & H.A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Research Center for Adaptive Data Analysis, National Central University, Chungli, Taiwan

    X
  • Chung-Kang Peng,

    Affiliations: Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan, Division of Interdisciplinary Medicine & Biotechnology and Margret & H.A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Yanhui Liu,

    Affiliation: DynaDx Corporation, Mountain View, California, United States of America

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  • Vera Novak

    Affiliations: Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan

    X
  • Published: July 12, 2012
  • DOI: 10.1371/journal.pcbi.1002601

About the Authors

Kun Hu
Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Kun Hu, Men-Tzung Lo, Vera Novak
Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Kun Hu, Men-Tzung Lo, Chung-Kang Peng, Vera Novak
Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan
Men-Tzung Lo, Chung-Kang Peng
Division of Interdisciplinary Medicine & Biotechnology and Margret & H.A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Men-Tzung Lo
Research Center for Adaptive Data Analysis, National Central University, Chungli, Taiwan
Yanhui Liu
DynaDx Corporation, Mountain View, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KH CKP VN. Performed the experiments: KH VN. Analyzed the data: KH MTL YL. Contributed reagents/materials/analysis tools: KH MTL CKP YL. Wrote the paper: KH MTL VN.