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Research Article

Efficiency and Power as a Function of Sequence Coverage, SNP Array Density, and Imputation

  • Jason Flannick,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Joshua M. Korn,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America, Graduate Program in Biophysics, Harvard University, Cambridge, Massachusetts, United States of America

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  • Pierre Fontanillas,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • George B. Grant,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Eric Banks,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Mark A. Depristo,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • David Altshuler mail

    altshuler@molbio.mgh.harvard.edu

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics and Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 12, 2012
  • DOI: 10.1371/journal.pcbi.1002604

About the Authors

Jason Flannick, Joshua M. Korn, Pierre Fontanillas, George B. Grant, Eric Banks, Mark A. Depristo, David Altshuler
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Jason Flannick, Joshua M. Korn, David Altshuler
Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Joshua M. Korn
Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
Joshua M. Korn
Graduate Program in Biophysics, Harvard University, Cambridge, Massachusetts, United States of America
David Altshuler
Department of Genetics and Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: altshuler@molbio.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JF JMK DA. Performed the experiments: JF. Analyzed the data: JF. Contributed reagents/materials/analysis tools: JF JMK PF GBG EB MAD. Wrote the paper: JF MAD DA.