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Research Article

Mutation Induced Extinction in Finite Populations: Lethal Mutagenesis and Lethal Isolation

  • C. Scott Wylie mail,

    cscottwylie@gmail.com

    Affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

    Current address: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America.

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  • Eugene I. Shakhnovich

    Affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.pcbi.1002609

About the Authors

C. Scott Wylie, Eugene I. Shakhnovich
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: cscottwylie@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CSW EIS. Performed the experiments: CSW. Analyzed the data: CSW EIS. Contributed reagents/materials/analysis tools: CSW. Wrote the paper: CSW.