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Research Article

Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

  • Jae-Seong Yang equal contributor,

    equal contributor Contributed equally to this work with: Jae-Seong Yang, Sang Woo Seo

    Affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea

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  • Sang Woo Seo equal contributor,

    equal contributor Contributed equally to this work with: Jae-Seong Yang, Sang Woo Seo

    Affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea

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  • Sungho Jang,

    Affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea

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  • Gyoo Yeol Jung mail,

    sukim@postech.ac.kr (SK); gyjung@postech.ac.kr (GYJ)

    Affiliations: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea

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  • Sanguk Kim mail

    sukim@postech.ac.kr (SK); gyjung@postech.ac.kr (GYJ)

    Affiliations: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea, Division of IT Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea

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  • Published: July 12, 2012
  • DOI: 10.1371/journal.pcbi.1002612

About the Authors

Jae-Seong Yang, Gyoo Yeol Jung, Sanguk Kim
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea
Sang Woo Seo, Sungho Jang, Gyoo Yeol Jung
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea
Sanguk Kim
Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea
Sanguk Kim
Division of IT Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JSY SWS GYJ SK. Performed the experiments: JSY SWS SJ. Analyzed the data: JSY SWS. Contributed reagents/materials/analysis tools: JSY SWS SJ. Wrote the paper: JSY SWS GYJ SK.