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Research Article

Literature Based Drug Interaction Prediction with Clinical Assessment Using Electronic Medical Records: Novel Myopathy Associated Drug Interactions

  • Jon D. Duke equal contributor,

    equal contributor Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang

    Affiliation: Regenstrief Institute, Indianapolis, Indiana, United States of America

    X
  • Xu Han equal contributor,

    equal contributor Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang

    Affiliations: Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Zhiping Wang equal contributor,

    equal contributor Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang

    Affiliations: Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Abhinita Subhadarshini,

    Affiliation: Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Shreyas D. Karnik,

    Affiliation: Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Xiaochun Li,

    Affiliation: Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Stephen D. Hall,

    Affiliation: Eli Lilly Inc., Indianapolis, Indiana, United States of America

    X
  • Yan Jin,

    Affiliation: Eli Lilly Inc., Indianapolis, Indiana, United States of America

    X
  • J. Thomas Callaghan,

    Affiliation: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Marcus J. Overhage,

    Affiliation: Siemens, Malvern, Pennsylvania, United States of America

    X
  • David A. Flockhart,

    Affiliations: Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America

    X
  • R. Matthew Strother,

    Affiliations: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Sara K. Quinney,

    Affiliations: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America, Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Lang Li mail

    lali@iupui.edu

    Affiliations: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Published: August 09, 2012
  • DOI: 10.1371/journal.pcbi.1002614

About the Authors

Jon D. Duke
Regenstrief Institute, Indianapolis, Indiana, United States of America
Xu Han, David A. Flockhart
Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
Xu Han, J. Thomas Callaghan, David A. Flockhart, R. Matthew Strother, Sara K. Quinney, Lang Li
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
Zhiping Wang, Abhinita Subhadarshini, Shreyas D. Karnik, David A. Flockhart, Lang Li
Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
Zhiping Wang, David A. Flockhart, Lang Li
Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
Xiaochun Li, Lang Li
Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
Stephen D. Hall, Yan Jin
Eli Lilly Inc., Indianapolis, Indiana, United States of America
Marcus J. Overhage
Siemens, Malvern, Pennsylvania, United States of America
David A. Flockhart, Sara K. Quinney, Lang Li
Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America
R. Matthew Strother
Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, Indiana, United States of America
Sara K. Quinney
Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

Corresponding Author

Email: lali@iupui.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDD XL SDH YJ JTC MJO DAF RMS SKQ LL. Performed the experiments: JDD XH ZW AS SDK LL. Analyzed the data: XH ZW LL. Wrote the paper: JDD XL SKQ LL. Proposed the whole picture of the DDI research project: LL. Guided all the data analyses: LL. Finalized the writing of the paper: LL. Contributed to the pharmaco-epidemiology design: JDD XL RMS SKQ. Contributed to the interpretation of the DDI results: JDD RMS SKQ. Performed the DDI/myopathy association analysis: XH. Provided the mechanistic interpretation of DDIs: SDH. Curated the data: XH AS SDK. Performed the EMR data mapping, data extraction and merging, and analyzable data preparation: ZW. Performed the literature mining: AS SDK. Contributed to the initial ideas formulation: SDH YJ JTC MJO. Contributed to the analysis strategy: XL.