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Research Article

The Role of Local Backrub Motions in Evolved and Designed Mutations

  • Daniel A. Keedy mail,

    daniel.keedy@gmail.com

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Ivelin Georgiev,

    Affiliation: Department of Computer Science, Duke University, Durham, North Carolina, United States of America

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  • Edward B. Triplett,

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Bruce R. Donald,

    Affiliations: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Computer Science, Duke University, Durham, North Carolina, United States of America

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  • David C. Richardson,

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Jane S. Richardson

    Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.pcbi.1002629

About the Authors

Daniel A. Keedy, Edward B. Triplett, Bruce R. Donald, David C. Richardson, Jane S. Richardson
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
Ivelin Georgiev, Bruce R. Donald
Department of Computer Science, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: daniel.keedy@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DAK IG EBT BRD DCR JSR. Performed the experiments: DAK IG EBT. Contributed reagents/materials/analysis tools: DAK JSR. Wrote the paper: DAK IG BRD DCR JSR.