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Research Article

The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

  • Deena M. A. Gendoo,

    Affiliations: Department of Biology, McGill University, Montreal, Quebec, Canada, McGill Center for Bioinformatics, McGill University, Montreal, Quebec, Canada

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  • Paul M. Harrison mail

    paul.harrison@mcgill.ca

    Affiliations: Department of Biology, McGill University, Montreal, Quebec, Canada, McGill Center for Bioinformatics, McGill University, Montreal, Quebec, Canada

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  • Published: August 09, 2012
  • DOI: 10.1371/journal.pcbi.1002646

About the Authors

Deena M. A. Gendoo, Paul M. Harrison
Department of Biology, McGill University, Montreal, Quebec, Canada
Deena M. A. Gendoo, Paul M. Harrison
McGill Center for Bioinformatics, McGill University, Montreal, Quebec, Canada

Corresponding Author

Email: paul.harrison@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMAG PMH. Performed the experiments: DMAG. Analyzed the data: DMAG PMH. Contributed reagents/materials/analysis tools: DMAG. Wrote the paper: DMAG PMH.