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Research Article

Defining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case

  • Rebeca García-Fandiño,

    Affiliations: Joint IRB BSC Program in Computational Biology, Institute for Research in Biomedicine, Barcelona, Spain, Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials, Santiago de Compostela University, Santiago de Compostela, Spain

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  • Pau Bernadó,

    Affiliation: Centre de Biochimie Structurale, INSERM U1054, CNRS UMR 5048, Université Montpellier 1 and 2, Montpellier, France

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  • Sara Ayuso-Tejedor,

    Affiliations: Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain, Joint Unit BIFI-IQFR, CSIC, Spain, Biocomputation and Physics of Complex Systems Institute (BIFI), Universidad de Zaragoza, Zaragoza, Spain

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  • Javier Sancho,

    Affiliations: Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain, Joint Unit BIFI-IQFR, CSIC, Spain, Biocomputation and Physics of Complex Systems Institute (BIFI), Universidad de Zaragoza, Zaragoza, Spain

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  • Modesto Orozco mail

    modesto.orozco@irbbarcelona.org

    Affiliations: Joint IRB BSC Program in Computational Biology, Institute for Research in Biomedicine, Barcelona, Spain, Departament de Bioquímica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain

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  • Published: August 23, 2012
  • DOI: 10.1371/journal.pcbi.1002647

About the Authors

Rebeca García-Fandiño, Modesto Orozco
Joint IRB BSC Program in Computational Biology, Institute for Research in Biomedicine, Barcelona, Spain
Rebeca García-Fandiño
Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials, Santiago de Compostela University, Santiago de Compostela, Spain
Pau Bernadó
Centre de Biochimie Structurale, INSERM U1054, CNRS UMR 5048, Université Montpellier 1 and 2, Montpellier, France
Sara Ayuso-Tejedor, Javier Sancho
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
Sara Ayuso-Tejedor, Javier Sancho
Joint Unit BIFI-IQFR, CSIC, Spain, Biocomputation and Physics of Complex Systems Institute (BIFI), Universidad de Zaragoza, Zaragoza, Spain
Modesto Orozco
Departament de Bioquímica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain

Corresponding Author

Email: modesto.orozco@irbbarcelona.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS MO. Performed the experiments: RGF. Analyzed the data: RGF MO. Contributed reagents/materials/analysis tools: PB SAT. Wrote the paper: MO.