Advertisement
Research Article

Spontaneous Excitation Patterns Computed for Axons with Injury-like Impairments of Sodium Channels and Na/K Pumps

  • Na Yu,

    Affiliation: Department of Physics, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Catherine E. Morris,

    Affiliation: Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

    X
  • Béla Joós mail,

    bjoos@uottawa.ca

    Affiliation: Department of Physics, University of Ottawa, Ottawa, Ontario, Canada

    X
  • André Longtin

    Affiliation: Department of Physics, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Published: September 13, 2012
  • DOI: 10.1371/journal.pcbi.1002664

About the Authors

Na Yu, Béla Joós, André Longtin
Department of Physics, University of Ottawa, Ottawa, Ontario, Canada
Catherine E. Morris
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Corresponding Author

Email: bjoos@uottawa.ca

Competing Interests

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author Contributions

Conceived and designed the experiments: CEM BJ AL. Wrote the paper: NY CEM BJ AL. Performed the simulations: NY. Performed the mathematical and dynamical analysis: NY BJ AL. Linked findings to excitable cell injury: CEM. Revised the manuscript BJ AL CEM.