Correlated Electrostatic Mutations Provide a Reservoir of Stability in HIV Protease

Omar Haq; Michael Andrec; Alexandre V. Morozov; Ronald M. Levy

doi:10.1371/journal.pcbi.1002675

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Open Access

Peer-reviewed

Research Article

Correlated Electrostatic Mutations Provide a Reservoir of Stability in HIV Protease

Omar Haq,

Affiliation BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America
⨯
Michael Andrec,

Affiliations BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Alexandre V. Morozov,

Affiliations BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America, Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Ronald M. Levy

* E-mail: ronlevy@lutece.rutgers.edu

Affiliations BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯

Correlated Electrostatic Mutations Provide a Reservoir of Stability in HIV Protease

Omar Haq,
Michael Andrec,
Alexandre V. Morozov,
Ronald M. Levy

Published: September 6, 2012
https://doi.org/10.1371/journal.pcbi.1002675

About the Authors

Omar Haq

Affiliation BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America

Michael Andrec

Affiliations BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

Alexandre V. Morozov

Affiliations BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States America, Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey, United States of America

Ronald M. Levy

* E-mail: ronlevy@lutece.rutgers.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AVM RML. Performed the experiments: OH MA AVM RML. Analyzed the data: OH MA AVM RML. Wrote the paper: OH MA AVM RML.

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Mutation databases
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Electrostatics
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HIV
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Proteases
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Point mutation
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Sequence databases
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Probability distribution
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Protein folding
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