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Research Article

Convergent Transmission of RNAi Guide-Target Mismatch Information across Argonaute Internal Allosteric Network

  • Thomas T. Joseph,

    Affiliations: Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Computational Biology Program, New York University, New York, New York, United States of America

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  • Roman Osman mail

    roman.osman@mssm.edu

    Affiliations: Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Computational Biology Program, New York University, New York, New York, United States of America

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.pcbi.1002693

About the Authors

Thomas T. Joseph, Roman Osman
Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America
Thomas T. Joseph, Roman Osman
Computational Biology Program, New York University, New York, New York, United States of America

Corresponding Author

Email: roman.osman@mssm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TTJ RO. Performed the experiments: TTJ. Analyzed the data: TTJ. Contributed reagents/materials/analysis tools: TTJ. Wrote the paper: TTJ.