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Research Article

Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes

  • Yuanfang Guan,

    Affiliations: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Dmitriy Gorenshteyn,

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Margit Burmeister,

    Affiliations: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Molecular & Behavioral Neuroscience Institution, Department of Psychiatry, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Aaron K. Wong,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • John C. Schimenti,

    Affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America

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  • Mary Ann Handel,

    Affiliation: The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Carol J. Bult,

    Affiliation: The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Matthew A. Hibbs mail,

    matt.hibbs@jax.org (MAH); ogt@genomics.princeton.edu (OGT)

    Affiliations: The Jackson Laboratory, Bar Harbor, Maine, United States of America, Trinity University, Computer Science Department, San Antonio, Texas, United States of America

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  • Olga G. Troyanskaya mail

    matt.hibbs@jax.org (MAH); ogt@genomics.princeton.edu (OGT)

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.pcbi.1002694

About the Authors

Yuanfang Guan, Margit Burmeister
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
Yuanfang Guan
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Dmitriy Gorenshteyn, Aaron K. Wong, Olga G. Troyanskaya
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
Dmitriy Gorenshteyn
Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
Margit Burmeister
Molecular & Behavioral Neuroscience Institution, Department of Psychiatry, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
John C. Schimenti
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
Mary Ann Handel, Carol J. Bult, Matthew A. Hibbs
The Jackson Laboratory, Bar Harbor, Maine, United States of America
Matthew A. Hibbs
Trinity University, Computer Science Department, San Antonio, Texas, United States of America
Olga G. Troyanskaya
Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Y. Guan, M. Burmeister, C. Bult, M. Hibbs, O. Troyanskaya. Performed the experiments: M. Burmeister, J. Schimenti, M. Handel. Analyzed the data: Y. Guan, M. Burmeister, M. Hibbs, O. Troyanskaya. Wrote the paper: Y. Guan, M. Burmeister, C. Bult, M. Hibbs, O. Troyanskaya. Developed web interface for network comparative viewing: D. Gorenshteyn, A. Wong.