Advertisement
Research Article

Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function

  • Michael A. Jamros,

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

    X
  • Leandro C. Oliveira,

    Affiliation: Laboratório Nacional de Ciência e Tecnologia do Bioetanol – CTBE/CNPEM, Campinas, São Paulo, Brazil

    X
  • Paul C. Whitford,

    Affiliation: Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America

    X
  • José N. Onuchic,

    Affiliation: Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America

    X
  • Joseph A. Adams,

    Affiliation: Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

    X
  • Patricia A. Jennings mail

    pajennin@ucsd.edu

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

    X
  • Published: September 20, 2012
  • DOI: 10.1371/journal.pcbi.1002695

About the Authors

Michael A. Jamros, Patricia A. Jennings
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
Leandro C. Oliveira
Laboratório Nacional de Ciência e Tecnologia do Bioetanol – CTBE/CNPEM, Campinas, São Paulo, Brazil
Paul C. Whitford, José N. Onuchic
Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
Joseph A. Adams
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: pajennin@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAJ LCO PCW JNO PAJ. Performed the experiments: MAJ LCO PCW. Analyzed the data: MAJ PCO PCW PAJ. Contributed reagents/materials/analysis tools: PCW JNO PAJ. Wrote the paper: MAJ LCO PCW PAJ JAA.