Advertisement
Research Article

Multistationary and Oscillatory Modes of Free Radicals Generation by the Mitochondrial Respiratory Chain Revealed by a Bifurcation Analysis

  • Vitaly A. Selivanov mail,

    selivanov@ub.edu (VAS); martacascante@ub.edu (MC)

    Affiliations: Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Barcelona, Spain, A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

    X
  • Marta Cascante mail,

    selivanov@ub.edu (VAS); martacascante@ub.edu (MC)

    Affiliations: Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Barcelona, Spain

    X
  • Mark Friedman,

    Affiliation: Mathematical Sciences Department, University of Alabama Huntsville, Huntsville, Alabama, United States of America

    X
  • Mark F. Schumaker,

    Affiliation: Department of Mathematics, Washington State University, Pullman, Washington, United States of America

    X
  • Massimo Trucco,

    Affiliation: Department of Pediatrics, The University of Pittsburgh School of Medicine and The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Tatyana V. Votyakova

    Affiliation: Department of Pediatrics, The University of Pittsburgh School of Medicine and The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: September 20, 2012
  • DOI: 10.1371/journal.pcbi.1002700

About the Authors

Vitaly A. Selivanov, Marta Cascante
Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain
Vitaly A. Selivanov, Marta Cascante
Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Barcelona, Spain
Vitaly A. Selivanov
A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia
Mark Friedman
Mathematical Sciences Department, University of Alabama Huntsville, Huntsville, Alabama, United States of America
Mark F. Schumaker
Department of Mathematics, Washington State University, Pullman, Washington, United States of America
Massimo Trucco, Tatyana V. Votyakova
Department of Pediatrics, The University of Pittsburgh School of Medicine and The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VAS TVV. Performed the experiments: TVV. Analyzed the data: VAS MC MF MFS MT TVV. Contributed reagents/materials/analysis tools: VAS TVV. Wrote the paper: VAS MC MF MFS MT TVV.