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Research Article

Coupling between Catalytic Loop Motions and Enzyme Global Dynamics

  • Zeynep Kurkcuoglu,

    Affiliation: Department of Chemical Engineering and Polymer Research Center, Bogazici University, Bebek, Istanbul, Turkey

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  • Ahmet Bakan,

    Affiliation: Department of Computational and Systems Biology, and Clinical & Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Duygu Kocaman,

    Affiliation: Department of Chemical Engineering and Polymer Research Center, Bogazici University, Bebek, Istanbul, Turkey

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  • Ivet Bahar mail,

    bahar@pitt.edu (IB); pemra@prc.boun.edu.tr (PD)

    Affiliation: Department of Computational and Systems Biology, and Clinical & Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Pemra Doruker mail

    bahar@pitt.edu (IB); pemra@prc.boun.edu.tr (PD)

    Affiliation: Department of Chemical Engineering and Polymer Research Center, Bogazici University, Bebek, Istanbul, Turkey

    X
  • Published: September 27, 2012
  • DOI: 10.1371/journal.pcbi.1002705

About the Authors

Zeynep Kurkcuoglu, Duygu Kocaman, Pemra Doruker
Department of Chemical Engineering and Polymer Research Center, Bogazici University, Bebek, Istanbul, Turkey
Ahmet Bakan, Ivet Bahar
Department of Computational and Systems Biology, and Clinical & Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IB PD. Performed the experiments: ZK AB DK. Analyzed the data: ZK AB DK IB PD. Wrote the paper: ZK AB DK IB PD.