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Research Article

Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder

  • Vladimir Vacic,

    Affiliation: Department of Computer Science, Columbia University, New York, New York, United States of America

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  • Phineus R. L. Markwick,

    Affiliations: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Christopher J. Oldfield,

    Affiliation: Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Xiaoyue Zhao,

    Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

    Current address: Google Inc, Mountain View, California, United States of America

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  • Chad Haynes,

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

    Current address: WaterSmart Software, San Francisco, California, United States of America

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  • Vladimir N. Uversky,

    Affiliations: Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, Florida, United States of America, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

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  • Lilia M. Iakoucheva mail

    lilyak@ucsd.edu

    Affiliation: Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.pcbi.1002709

About the Authors

Vladimir Vacic
Department of Computer Science, Columbia University, New York, New York, United States of America
Phineus R. L. Markwick
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
Phineus R. L. Markwick
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
Christopher J. Oldfield
Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Xiaoyue Zhao
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
Chad Haynes
Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America
Vladimir N. Uversky
Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, Florida, United States of America
Vladimir N. Uversky
Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Lilia M. Iakoucheva
Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: lilyak@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VV LMI. Performed the experiments: VV PRLM CJO XZ CH. Analyzed the data: VV LMI. Contributed reagents/materials/analysis tools: PRLM CJO. Wrote the paper: VV PRLM VNU LMI.