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Research Article

Molecular Mechanism for the Dual Alcohol Modulation of Cys-loop Receptors

  • Samuel Murail,

    Affiliations: Science for Life Laboratory, KTH Royal Institute of Technology & Stockholm University, Stockholm, Sweden, Center for Biomembrane Research, Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden

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  • Rebecca J. Howard,

    Affiliation: Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of America

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  • Torben Broemstrup,

    Affiliations: Science for Life Laboratory, KTH Royal Institute of Technology & Stockholm University, Stockholm, Sweden, Center for Biomembrane Research, Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden

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  • Edward J. Bertaccini,

    Affiliations: Department of Anesthesia, Palo Alto Veterans Affairs Health Care System, Palo Alto, California, United States of America, Department of Anesthesia and Beckman Program for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, United States of America

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  • R. Adron Harris,

    Affiliation: Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of America

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  • James R. Trudell,

    Affiliation: Department of Anesthesia and Beckman Program for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, United States of America

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  • Erik Lindahl mail

    erik@kth.se

    Affiliations: Science for Life Laboratory, KTH Royal Institute of Technology & Stockholm University, Stockholm, Sweden, Center for Biomembrane Research, Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.pcbi.1002710

About the Authors

Samuel Murail, Torben Broemstrup, Erik Lindahl
Science for Life Laboratory, KTH Royal Institute of Technology & Stockholm University, Stockholm, Sweden
Samuel Murail, Torben Broemstrup, Erik Lindahl
Center for Biomembrane Research, Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden
Rebecca J. Howard, R. Adron Harris
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of America
Edward J. Bertaccini
Department of Anesthesia, Palo Alto Veterans Affairs Health Care System, Palo Alto, California, United States of America
Edward J. Bertaccini, James R. Trudell
Department of Anesthesia and Beckman Program for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, United States of America

Corresponding Author

Email: erik@kth.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM EJB RAH JRT EL. Performed the experiments: SM TB. Analyzed the data: SM RJH EJB EL. Contributed reagents/materials/analysis tools: SM EJB JRT EL. Wrote the paper: SM RJH TB EJB RAH JRT EL.