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Research Article

Confidence-based Somatic Mutation Evaluation and Prioritization

  • Martin Löwer equal contributor,

    equal contributor Contributed equally to this work with: Martin Löwer, Bernhard Y. Renard

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

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  • Bernhard Y. Renard equal contributor,

    equal contributor Contributed equally to this work with: Martin Löwer, Bernhard Y. Renard

    Affiliations: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany, Research Group Bioinformatics (NG 4), Robert Koch-Institut, Berlin, Germany

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  • Jos de Graaf,

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

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  • Meike Wagner,

    Affiliations: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany, Department of Internal Medicine III, Division of Translational and Experimental Oncology, University Medical Center, Johannes Gutenberg University, Mainz, Germany

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  • Claudia Paret,

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

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  • Christoph Kneip,

    Affiliation: Theracode GmbH, Mainz, Germany

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  • Özlem Türeci,

    Affiliation: Ganymed Pharmaceuticals AG, Mainz, Germany

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  • Mustafa Diken,

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

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  • Cedrik Britten,

    Affiliation: Ribological GmbH, Mainz, Germany

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  • Sebastian Kreiter,

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

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  • Michael Koslowski,

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

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  • John C. Castle mail,

    john.castle@tron-mainz.de (JCC); sahin@uni-mainz.de (US)

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

    These authors are joint senior authors on this work.

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  • Ugur Sahin mail

    john.castle@tron-mainz.de (JCC); sahin@uni-mainz.de (US)

    Affiliation: TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany

    These authors are joint senior authors on this work.

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.pcbi.1002714

About the Authors

Martin Löwer, Bernhard Y. Renard, Jos de Graaf, Meike Wagner, Claudia Paret, Mustafa Diken, Sebastian Kreiter, Michael Koslowski, John C. Castle, Ugur Sahin
TRON - Translational Oncology at the Johannes Gutenberg University of Mainz Medicine, Mainz, Germany
Bernhard Y. Renard
Research Group Bioinformatics (NG 4), Robert Koch-Institut, Berlin, Germany
Meike Wagner
Department of Internal Medicine III, Division of Translational and Experimental Oncology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
Christoph Kneip
Theracode GmbH, Mainz, Germany
Özlem Türeci
Ganymed Pharmaceuticals AG, Mainz, Germany
Cedrik Britten
Ribological GmbH, Mainz, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ÖT MD CB SK MK JCC US. Performed the experiments: JdG MW CP CK. Analyzed the data: ML BYR JCC. Contributed reagents/materials/analysis tools: MD. Wrote the paper: ML BYR JCC. Designed the software used in analysis: ML BYR JCC Implemented the software: ML BYR Processed the sequencing data: ML.