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Research Article

MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells

  • Aurélie Carlier,

    Affiliations: Biomechanics Section, KU Leuven, Leuven, Belgium, Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Leuven, Belgium, Biomechanics Research Unit, University of Liege, Liege, Belgium

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  • Liesbet Geris,

    Affiliations: Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Leuven, Belgium, Biomechanics Research Unit, University of Liege, Liege, Belgium

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  • Katie Bentley,

    Affiliation: Vascular Biology Lab, Cancer Research UK, London, United Kingdom

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  • Geert Carmeliet,

    Affiliation: Clinical and Experimental Endocrinology, KU Leuven, O&N 1, Leuven, Belgium

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  • Peter Carmeliet,

    Affiliations: Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, University of Leuven, Leuven, Belgium

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  • Hans Van Oosterwyck mail

    hans.vanoosterwyck@mech.kuleuven.be

    Affiliations: Biomechanics Section, KU Leuven, Leuven, Belgium, Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Leuven, Belgium

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pcbi.1002724

About the Authors

Aurélie Carlier, Hans Van Oosterwyck
Biomechanics Section, KU Leuven, Leuven, Belgium
Aurélie Carlier, Liesbet Geris, Hans Van Oosterwyck
Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Leuven, Belgium
Aurélie Carlier, Liesbet Geris
Biomechanics Research Unit, University of Liege, Liege, Belgium
Katie Bentley
Vascular Biology Lab, Cancer Research UK, London, United Kingdom
Geert Carmeliet
Clinical and Experimental Endocrinology, KU Leuven, O&N 1, Leuven, Belgium
Peter Carmeliet
Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium
Peter Carmeliet
Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, University of Leuven, Leuven, Belgium

Corresponding Author

Email: hans.vanoosterwyck@mech.kuleuven.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AC LG KB HVO. Performed the experiments: AC. Analyzed the data: AC LG KB GC PC HVO. Contributed reagents/materials/analysis tools: AC KB. Wrote the paper: AC LG KB GC PC HVO.