About the Authors

Markus Krauss

Affiliations Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany, Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany

Stephan Schaller

Affiliations Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany, Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany

Steffen Borchers

Affiliation Laboratory for Systems Theory and Automatic Control, Institute for Automation Engineering, Otto-von-Guericke University, Magdeburg, Germany

Rolf Findeisen

Affiliation Laboratory for Systems Theory and Automatic Control, Institute for Automation Engineering, Otto-von-Guericke University, Magdeburg, Germany

Jörg Lippert

Affiliation Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany

Lars Kuepfer

Lars.Kuepfer@bayer.com

Affiliations Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany, Institute of Applied Microbiology, RWTH Aachen, Aachen, Germany

Competing Interests

MK, SS, JL, and LK are employees of Bayer Technology Services GmbH, the company developing PK-Sim® and MoBi®.

Author Contributions

Conceived and designed the experiments: MK SS JL LK. Performed the experiments: MK SS LK. Analyzed the data: MK SS SB RF JL LK. Wrote the paper: MK SS SB RF JL LK.