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Research Article

Dynamic Control of Selectivity in the Ubiquitination Pathway Revealed by an ASP to GLU Substitution in an Intra-Molecular Salt-Bridge Network

  • Sjoerd J. L. van Wijk equal contributor,

    equal contributor Contributed equally to this work with: Sjoerd J. L. van Wijk, Adrien S. J. Melquiond

    Affiliation: Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands

    Current address: Institute of Biochemistry II and Buchman Institute for Molecular Life Sciences (FMLS), Goethe University School of Medicine, University Hospital, Frankfurt am Main, Germany.

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  • Adrien S. J. Melquiond equal contributor,

    equal contributor Contributed equally to this work with: Sjoerd J. L. van Wijk, Adrien S. J. Melquiond

    Affiliation: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

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  • Sjoerd J. de Vries,

    Affiliation: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

    Current address: Biomolecular Dynamics, Department of Physics T38, Technical University M√ľnchen, Garching, Germany.

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  • H. Th. Marc Timmers,

    Affiliation: Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Alexandre M. J. J. Bonvin mail

    A.M.J.J.Bonvin@uu.nl

    Affiliation: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

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  • Published: November 01, 2012
  • DOI: 10.1371/journal.pcbi.1002754

About the Authors

Sjoerd J. L. van Wijk, H. Th. Marc Timmers
Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
Adrien S. J. Melquiond, Sjoerd J. de Vries, Alexandre M. J. J. Bonvin
Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

Corresponding Author

Email: A.M.J.J.Bonvin@uu.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJLvW ASJM SJdV HTMT AMJJB. Performed the experiments: SJLvW ASJM. Analyzed the data: SJLvW ASJM SJdV HTMT AMJJB. Contributed reagents/materials/analysis tools: HTMT AMJJB. Wrote the paper: SJLvW ASJM SJdV HTMT AMJJB.