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Research Article

Chemotactic Migration of T Cells towards Dendritic Cells Promotes the Detection of Rare Antigens

  • Renske M. A. Vroomans,

    Affiliation: Theoretical Biology, Utrecht University, Utrecht, The Netherlands

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  • Athanasius F. M. Marée,

    Affiliation: Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom

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  • Rob J. de Boer,

    Affiliation: Theoretical Biology, Utrecht University, Utrecht, The Netherlands

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  • Joost B. Beltman mail

    J.B.Beltman@uu.nl

    Affiliations: Theoretical Biology, Utrecht University, Utrecht, The Netherlands, Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pcbi.1002763

About the Authors

Renske M. A. Vroomans, Rob J. de Boer, Joost B. Beltman
Theoretical Biology, Utrecht University, Utrecht, The Netherlands
Athanasius F. M. Marée
Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom
Joost B. Beltman
Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Corresponding Author

Email: J.B.Beltman@uu.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMAV RJB JBB. Performed the experiments: RMAV. Analyzed the data: RMAV AFMM RJB JBB . Contributed reagents/materials/analysis tools: AFMM JBB. Wrote the paper: RMAV AFMM RJB JBB. Designed the environment for the Cellular Potts Model simulations: AFMM.