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Research Article

Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay

  • Filippo Cacace equal contributor,

    equal contributor Contributed equally to this work with: Filippo Cacace, Paola Paci

    Affiliation: Università Campus Biomedico, Rome, Italy

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  • Paola Paci equal contributor mail,

    equal contributor Contributed equally to this work with: Filippo Cacace, Paola Paci

    paola.paci@iasi.cnr.it

    Affiliations: Università Campus Biomedico, Rome, Italy, CNR-Institute of Systems Analysis and Computer Science (IASI), BioMathLab, Rome, Italy

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  • Valerio Cusimano,

    Affiliation: Università Campus Biomedico, Rome, Italy

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  • Alfredo Germani,

    Affiliation: Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica (DISIM), Università de L'Aquila, L'Aquila, Italy

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  • Lorenzo Farina

    Affiliation: Dipartimento di Informatica e Sistemistica, Sapienza Università di Roma, Rome, Italy

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pcbi.1002772

About the Authors

Filippo Cacace, Paola Paci, Valerio Cusimano
Università Campus Biomedico, Rome, Italy
Paola Paci
CNR-Institute of Systems Analysis and Computer Science (IASI), BioMathLab, Rome, Italy
Alfredo Germani
Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica (DISIM), Università de L'Aquila, L'Aquila, Italy
Lorenzo Farina
Dipartimento di Informatica e Sistemistica, Sapienza Università di Roma, Rome, Italy

Corresponding Author

Email: paola.paci@iasi.cnr.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LF AG. Performed the experiments: FC PP VC. Analyzed the data: PP LF. Wrote the paper: FC PP AG LF. Made the figures: LF.