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Research Article

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

  • Peter Michael Kekenes-Huskey mail,

    pkekeneshuskey@ucsd.edu

    Affiliation: Department of Pharmacology, Center for Theoretical Biological Physics, National Computational Biomedical Resource and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

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  • Steffen Lindert,
  • James Andrew McCammon
  • Published: November 29, 2012
  • DOI: 10.1371/journal.pcbi.1002777

About the Authors

Peter Michael Kekenes-Huskey
Department of Pharmacology, Center for Theoretical Biological Physics, National Computational Biomedical Resource and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: pkekeneshuskey@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PMKH SL JAM. Performed the experiments: PMKH SL. Analyzed the data: PMKH SL JAM. Contributed reagents/materials/analysis tools: PMKH SL. Wrote the paper: PMKH SL JAM.