Molecular Evolution of Peptide Ligands with Custom-Tailored Characteristics for Targeting of Glycostructures

Niels Röckendorf; Markus Borschbach; Andreas Frey

doi:10.1371/journal.pcbi.1002800

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Open Access

Peer-reviewed

Research Article

Molecular Evolution of Peptide Ligands with Custom-Tailored Characteristics for Targeting of Glycostructures

Niels Röckendorf ,

Contributed equally to this work with: Niels Röckendorf, Markus Borschbach

Affiliation Division of Mucosal Immunology & Diagnostics, Priority Program Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany
⨯
Markus Borschbach ,

Contributed equally to this work with: Niels Röckendorf, Markus Borschbach

Affiliation FHDW, University of Applied Sciences, Bergisch Gladbach, Germany
⨯
Andreas Frey

* E-mail: afrey@fz-borstel.de

Affiliation Division of Mucosal Immunology & Diagnostics, Priority Program Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany
⨯

Molecular Evolution of Peptide Ligands with Custom-Tailored Characteristics for Targeting of Glycostructures

Niels Röckendorf,
Markus Borschbach,
Andreas Frey

Published: December 13, 2012
https://doi.org/10.1371/journal.pcbi.1002800

About the Authors

Niels Röckendorf

Contributed equally to this work with: Niels Röckendorf, Markus Borschbach

Affiliation Division of Mucosal Immunology & Diagnostics, Priority Program Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany

Markus Borschbach

Contributed equally to this work with: Niels Röckendorf, Markus Borschbach

Affiliation FHDW, University of Applied Sciences, Bergisch Gladbach, Germany

Andreas Frey

* E-mail: afrey@fz-borstel.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NR AF. Performed the experiments: NR. Analyzed the data: NR. Wrote the paper: NR MB AF. Created the evolutionary algorithm software: MB. Developed the concept and supervised the study: AF.

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Protein sequencing
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Evolutionary processes
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Optimization
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Peptide synthesis
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Reaction time
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Evolutionary algorithms
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Peptide libraries
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Sequence motif analysis
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