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Research Article

Novel Modeling of Combinatorial miRNA Targeting Identifies SNP with Potential Role in Bone Density

  • Claudia Coronnello mail,

    clc196@pitt.edu (CC); benos@pitt.edu (PVB)

    Affiliations: Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Fondazione Ri.MED, Palermo, Italy

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  • Ryan Hartmaier,

    Affiliation: Department of Pharmacology and Chemical Biology, Womens Cancer Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Arshi Arora,

    Affiliation: Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Luai Huleihel,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Kusum V. Pandit,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Abha S. Bais,

    Affiliation: Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Michael Butterworth,

    Affiliation: Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Naftali Kaminski,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Gary D. Stormo,

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Steffi Oesterreich,

    Affiliation: Department of Pharmacology and Chemical Biology, Womens Cancer Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Panayiotis V. Benos mail

    clc196@pitt.edu (CC); benos@pitt.edu (PVB)

    Affiliations: Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Published: December 20, 2012
  • DOI: 10.1371/journal.pcbi.1002830

About the Authors

Claudia Coronnello, Arshi Arora, Abha S. Bais, Panayiotis V. Benos
Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Claudia Coronnello
Fondazione Ri.MED, Palermo, Italy
Ryan Hartmaier, Steffi Oesterreich
Department of Pharmacology and Chemical Biology, Womens Cancer Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Luai Huleihel, Kusum V. Pandit, Naftali Kaminski
Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States of America
Michael Butterworth
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Gary D. Stormo
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Panayiotis V. Benos
Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CC RH NK GDS SO PVB. Performed the experiments: CC RH LH KVP. Analyzed the data: CC RH AA ASB NK SO PVB. Contributed reagents/materials/analysis tools: CC MB NK SO. Wrote the paper: CC RH MB NK GDS SO PVB.