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Research Article

PERT: A Method for Expression Deconvolution of Human Blood Samples from Varied Microenvironmental and Developmental Conditions

  • Wenlian Qiao equal contributor,

    equal contributor Contributed equally to this work with: Wenlian Qiao, Gerald Quon

    Affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

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  • Gerald Quon equal contributor,

    equal contributor Contributed equally to this work with: Wenlian Qiao, Gerald Quon

    Affiliation: Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

    Current address: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Elizabeth Csaszar,

    Affiliations: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

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  • Mei Yu,

    Affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

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  • Quaid Morris mail,

    quaid.morris@utoronto.ca (QM); peter.zandstra@utoronto.ca (PWZ)

    Affiliations: Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

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  • Peter W. Zandstra mail

    quaid.morris@utoronto.ca (QM); peter.zandstra@utoronto.ca (PWZ)

    Affiliations: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada, McEwen Centre for Regenerative Medicine, University of Health Network, Toronto, Ontario, Canada, Heart & Stroke/Richard Lewar Centre of Excellence, Toronto, Ontario, Canada

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  • Published: December 20, 2012
  • DOI: 10.1371/journal.pcbi.1002838

About the Authors

Wenlian Qiao, Elizabeth Csaszar, Mei Yu, Peter W. Zandstra
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
Gerald Quon, Quaid Morris
Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Elizabeth Csaszar, Peter W. Zandstra
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Quaid Morris
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Quaid Morris
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
Quaid Morris
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
Peter W. Zandstra
McEwen Centre for Regenerative Medicine, University of Health Network, Toronto, Ontario, Canada
Peter W. Zandstra
Heart & Stroke/Richard Lewar Centre of Excellence, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WQ GQ QM PWZ. Performed the experiments: WQ GQ EC MY. Analyzed the data: WQ GQ. Contributed reagents/materials/analysis tools: GQ QM. Wrote the paper: WQ GQ QM PWZ.