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Research Article

Identification of a Functional Connectome for Long-Term Fear Memory in Mice

  • Anne L. Wheeler,

    Affiliations: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

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  • Cátia M. Teixeira,

    Affiliation: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada

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  • Afra H. Wang,

    Affiliations: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

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  • Xuejian Xiong,

    Affiliation: Program in Molecular Structure and Function, The Hospital for Sick Children, Toronto, Canada

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  • Natasa Kovacevic,

    Affiliation: Rotman Research Institute, Baycrest Centre, Toronto, Canada

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  • Jason P. Lerch,

    Affiliations: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Canada

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  • Anthony R. McIntosh,

    Affiliations: Rotman Research Institute, Baycrest Centre, Toronto, Canada, Department of Psychology, University of Toronto, Toronto, Canada

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  • John Parkinson,

    Affiliations: Program in Molecular Structure and Function, The Hospital for Sick Children, Toronto, Canada, Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Canada

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  • Paul W. Frankland mail

    paul.frankland@sickkids.ca

    Affiliations: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada, Department of Physiology, University of Toronto, Toronto, Canada

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pcbi.1002853
  • Featured in PLOS Collections

About the Authors

Anne L. Wheeler, Cátia M. Teixeira, Afra H. Wang, Jason P. Lerch, Paul W. Frankland
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada
Anne L. Wheeler, Afra H. Wang, Paul W. Frankland
Institute of Medical Science, University of Toronto, Toronto, Canada
Xuejian Xiong, John Parkinson
Program in Molecular Structure and Function, The Hospital for Sick Children, Toronto, Canada
Natasa Kovacevic, Anthony R. McIntosh
Rotman Research Institute, Baycrest Centre, Toronto, Canada
Jason P. Lerch
Department of Medical Biophysics, University of Toronto, Toronto, Canada
Anthony R. McIntosh
Department of Psychology, University of Toronto, Toronto, Canada
John Parkinson
Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Canada
Paul W. Frankland
Department of Physiology, University of Toronto, Toronto, Canada

Corresponding Author

Email: paul.frankland@sickkids.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ALW PWF. Performed the experiments: ALW CMT AHW PWF. Analyzed the data: ALW. Contributed reagents/materials/analysis tools: ARM. Wrote the paper: ALW PWF. Advised on statistical and graph theoretical analyses: XX NK JPL ARM JP.