Advertisement
Research Article

ADEMA: An Algorithm to Determine Expected Metabolite Level Alterations Using Mutual Information

  • A. Ercument Cicek mail,

    aec51@case.edu

    Affiliation: Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Ilya Bederman,

    Affiliation: Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Leigh Henderson,

    Affiliation: Department of Genetics and Genomic Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Mitchell L. Drumm,

    Affiliations: Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Genetics and Genomic Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Gultekin Ozsoyoglu

    Affiliation: Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Published: January 17, 2013
  • DOI: 10.1371/journal.pcbi.1002859

About the Authors

A. Ercument Cicek, Gultekin Ozsoyoglu
Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, United States of America
Ilya Bederman, Mitchell L. Drumm
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America
Leigh Henderson, Mitchell L. Drumm
Department of Genetics and Genomic Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America

Corresponding Author

Email: aec51@case.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed the technique and implemented the algorithm: AEC. Evaluation of the test results: IB LH MLD. Supervised the project: GO. Conceived and designed the experiments: AEC. Performed the experiments: AEC. Analyzed the data: AEC IB. Contributed reagents/materials/analysis tools: IB LH MLD. Wrote the paper: AEC IB LH.