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Research Article

Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions

  • Martin H. Schaefer,

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Tiago J. S. Lopes,

    Affiliation: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan

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  • Nancy Mah,

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Jason E. Shoemaker,

    Affiliation: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan

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  • Yukiko Matsuoka,

    Affiliations: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan, The Systems Biology Institute, Tokyo, Japan

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  • Jean-Fred Fontaine,

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Caroline Louis-Jeune,

    Affiliation: Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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  • Amie J. Eisfeld,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Gabriele Neumann,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Carol Perez-Iratxeta,

    Affiliation: Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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  • Yoshihiro Kawaoka,

    Affiliations: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan, Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Tokyo, Japan

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  • Hiroaki Kitano,

    Affiliations: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan, Sony Computer Science Laboratories, Inc., Tokyo, Japan, Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan, Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

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  • Miguel A. Andrade-Navarro mail

    miguel.andrade@mdc-berlin.de

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pcbi.1002860

About the Authors

Martin H. Schaefer, Nancy Mah, Jean-Fred Fontaine, Miguel A. Andrade-Navarro
Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany
Tiago J. S. Lopes, Jason E. Shoemaker, Yukiko Matsuoka, Yoshihiro Kawaoka, Hiroaki Kitano
JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan
Yukiko Matsuoka
The Systems Biology Institute, Tokyo, Japan
Caroline Louis-Jeune, Carol Perez-Iratxeta
Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Amie J. Eisfeld, Gabriele Neumann, Yoshihiro Kawaoka
Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Yoshihiro Kawaoka
Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Tokyo, Japan
Hiroaki Kitano
Sony Computer Science Laboratories, Inc., Tokyo, Japan
Hiroaki Kitano
Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
Hiroaki Kitano
Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

Corresponding Author

Email: miguel.andrade@mdc-berlin.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MHS TJSL YK HK MAAN. Analyzed the data: MHS TJSL NM JES YM JFF CLJ AJE GN CPI. Wrote the paper: MHS TJSL NM AJE GN MAAN.