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Research Article

Asymmetric PTEN Distribution Regulated by Spatial Heterogeneity in Membrane-Binding State Transitions

  • Satomi Matsuoka,

    Affiliations: Laboratory for Cell Signaling Dynamics, RIKEN Quantitative Biology Center, Suita, Japan, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan, CREST, Japan Science and Technology Agency (JST), Suita, Japan

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  • Tatsuo Shibata,

    Affiliations: CREST, Japan Science and Technology Agency (JST), Suita, Japan, Laboratories for Physical Biology, RIKEN Center for Developmental Biology, Kobe, Japan

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  • Masahiro Ueda mail

    ueda@bio.sci.osaka-u.ac.jp

    Affiliations: Laboratory for Cell Signaling Dynamics, RIKEN Quantitative Biology Center, Suita, Japan, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan, CREST, Japan Science and Technology Agency (JST), Suita, Japan, Laboratory of Single Molecule Biology, Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Japan

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  • Published: January 10, 2013
  • DOI: 10.1371/journal.pcbi.1002862

About the Authors

Satomi Matsuoka, Masahiro Ueda
Laboratory for Cell Signaling Dynamics, RIKEN Quantitative Biology Center, Suita, Japan
Satomi Matsuoka, Masahiro Ueda
Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
Satomi Matsuoka, Tatsuo Shibata, Masahiro Ueda
CREST, Japan Science and Technology Agency (JST), Suita, Japan
Tatsuo Shibata
Laboratories for Physical Biology, RIKEN Center for Developmental Biology, Kobe, Japan
Masahiro Ueda
Laboratory of Single Molecule Biology, Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Japan

Corresponding Author

Email: ueda@bio.sci.osaka-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM TS MU. Performed the experiments: SM. Analyzed the data: SM. Contributed reagents/materials/analysis tools: TS. Wrote the paper: SM MU.