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Research Article

Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin

  • Giovanni Settanni mail,

    settani@uni-mainz.de (GS); E.Paci@leeds.ac.uk (EP); lsi10@cam.ac.uk (LSI)

    Affiliation: Physics Department, Johannes Gutenberg University, Mainz, Germany

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  • David Serquera,

    Affiliation: MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Piotr E. Marszalek,

    Affiliation: Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, United States of America

    X
  • Emanuele Paci mail,

    settani@uni-mainz.de (GS); E.Paci@leeds.ac.uk (EP); lsi10@cam.ac.uk (LSI)

    Affiliation: School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

    X
  • Laura S. Itzhaki mail

    settani@uni-mainz.de (GS); E.Paci@leeds.ac.uk (EP); lsi10@cam.ac.uk (LSI)

    Affiliation: University of Cambridge Department of Chemistry, Cambridge, United Kingdom

    X
  • Published: January 17, 2013
  • DOI: 10.1371/journal.pcbi.1002864

About the Authors

Giovanni Settanni
Physics Department, Johannes Gutenberg University, Mainz, Germany
David Serquera
MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, United Kingdom
Piotr E. Marszalek
Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, United States of America
Emanuele Paci
School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
Laura S. Itzhaki
University of Cambridge Department of Chemistry, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS DS PEM EP LSI. Performed the experiments: GS. Analyzed the data: GS DS EP LSI. Contributed reagents/materials/analysis tools: GS DS EP. Wrote the paper: GS DS EP LSI.