Advertisement
Research Article

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

  • Thomas Lemmin,

    Affiliation: Laboratory for Biomolecular Modeling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

    X
  • Cinque S. Soto,

    Affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Graham Clinthorne,

    Affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • William F. DeGrado,

    Affiliation: Department of Pharmaceutical Chemistry, University of California – San Francisco, San Francisco, California, United States of America

    X
  • Matteo Dal Peraro mail

    matteo.dalperaro@epfl.ch

    Affiliation: Laboratory for Biomolecular Modeling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

    X
  • Published: January 24, 2013
  • DOI: 10.1371/journal.pcbi.1002878

About the Authors

Thomas Lemmin, Matteo Dal Peraro
Laboratory for Biomolecular Modeling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Cinque S. Soto, Graham Clinthorne
Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, United States of America
William F. DeGrado
Department of Pharmaceutical Chemistry, University of California – San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: matteo.dalperaro@epfl.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MDP. Performed the experiments: TL GC. Analyzed the data: TL CSS GC WFD MDP. Wrote the paper: TL CSS WFD MDP.