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Research Article

Metallochaperones Regulate Intracellular Copper Levels

  • W. Lee Pang,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

    Current address: Genomatica, Inc., San Diego, California, United States of America.

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  • Amardeep Kaur,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Alexander V. Ratushny,

    Affiliations: Institute for Systems Biology, Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Aleksandar Cvetkovic,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America

    Current address: Pall Life Sciences, Boston, Massachusetts, United States of America.

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  • Sunil Kumar,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America

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  • Min Pan,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Adam P. Arkin,

    Affiliation: Department of Bioengineering, University of California, Berkeley, California, United States of America

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  • John D. Aitchison,

    Affiliations: Institute for Systems Biology, Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Michael W. W. Adams,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America

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  • Nitin S. Baliga mail

    Nitin.Baliga@systemsbiology.org

    Affiliations: Institute for Systems Biology, Seattle, Washington, United States of America, Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Published: January 17, 2013
  • DOI: 10.1371/journal.pcbi.1002880

About the Authors

W. Lee Pang, Amardeep Kaur, Alexander V. Ratushny, Min Pan, John D. Aitchison, Nitin S. Baliga
Institute for Systems Biology, Seattle, Washington, United States of America
Alexander V. Ratushny, John D. Aitchison
Seattle Biomedical Research Institute, Seattle, Washington, United States of America
Aleksandar Cvetkovic, Sunil Kumar, Michael W. W. Adams
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America
Adam P. Arkin
Department of Bioengineering, University of California, Berkeley, California, United States of America
Nitin S. Baliga
Department of Microbiology, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: Nitin.Baliga@systemsbiology.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WLP NSB. Performed the experiments: WLP AK AC SK MP. Analyzed the data: WLP AVR APA JDA NSB. Contributed reagents/materials/analysis tools: AC SK MWWA. Wrote the paper: WLP NSB.