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Research Article

Binding of Nucleoid-Associated Protein Fis to DNA Is Regulated by DNA Breathing Dynamics

  • Kristy Nowak-Lovato,

    Affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Ludmil B. Alexandrov,

    Affiliation: Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    X
  • Afsheen Banisadr,

    Affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Amy L. Bauer,

    Affiliation: X-Theoretical Design Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Alan R. Bishop,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Anny Usheva,

    Affiliation: Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

    X
  • Fangping Mu,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Elizabeth Hong-Geller,

    Affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Kim Ø. Rasmussen,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • William S. Hlavacek mail,

    wish@lanl.gov (WSH); boian@lanl.gov (BSA)

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Boian S. Alexandrov mail

    wish@lanl.gov (WSH); boian@lanl.gov (BSA)

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Published: January 17, 2013
  • DOI: 10.1371/journal.pcbi.1002881

About the Authors

Kristy Nowak-Lovato, Afsheen Banisadr, Elizabeth Hong-Geller
Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Ludmil B. Alexandrov
Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Amy L. Bauer
X-Theoretical Design Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Alan R. Bishop, Fangping Mu, Kim Ø. Rasmussen, William S. Hlavacek, Boian S. Alexandrov
Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Anny Usheva
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KNL ARB EHG KOR WSH BSA. Performed the experiments: KNL AB EHG. Analyzed the data: LBA ALB ARB AU FM KOR WSH BSA. Wrote the paper: KNL LBA ARB EHG KOR WSH BSA.