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Research Article

Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling

  • Shao-shan Carol Huang,

    Affiliations: PhD Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    Current address: Plant Molecular and Cellular Biology Laboratory and Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America.

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  • David C. Clarke,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Cellular Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Sara J. C. Gosline,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Adam Labadorf,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Candace R. Chouinard,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • William Gordon,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    Current address: Departments of Medicine and Biological Chemistry, University of California, Irvine, Irvine, California, United States of America.

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  • Douglas A. Lauffenburger,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Cellular Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Ernest Fraenkel mail

    fraenkel-admin@mit.edu

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: February 07, 2013
  • DOI: 10.1371/journal.pcbi.1002887

About the Authors

Shao-shan Carol Huang
PhD Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Shao-shan Carol Huang, David C. Clarke, Sara J. C. Gosline, Adam Labadorf, Candace R. Chouinard, William Gordon, Douglas A. Lauffenburger, Ernest Fraenkel
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
David C. Clarke, Douglas A. Lauffenburger
Center for Cellular Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Ernest Fraenkel
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: fraenkel-admin@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSCH EF. Performed the experiments: SSCH CRC WG. Analyzed the data: SSCH DCC SJCG EF. Contributed reagents/materials/analysis tools: AL DAL. Wrote the paper: SSCH EF.