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Research Article

Using Steered Molecular Dynamics to Predict and Assess Hsp70 Substrate-Binding Domain Mutants that Alter Prion Propagation

  • Linan Xu,

    Affiliation: Province Key Laboratory of Animal Resource and Epidemic Disease Prevention, Liaoning University, Shenyang, China

    X
  • Naushaba Hasin,

    Affiliation: Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland

    X
  • Manli Shen,

    Affiliation: School of Environmental Science, Liaoning University, Shenyang, China

    X
  • Jianwei He,

    Affiliations: Province Key Laboratory of Animal Resource and Epidemic Disease Prevention, Liaoning University, Shenyang, China, School of Environmental Science, Liaoning University, Shenyang, China

    X
  • Youlin Xue,

    Affiliation: Province Key Laboratory of Animal Resource and Epidemic Disease Prevention, Liaoning University, Shenyang, China

    X
  • Xiaohong Zhou,

    Affiliation: Province Key Laboratory of Animal Resource and Epidemic Disease Prevention, Liaoning University, Shenyang, China

    X
  • Sarah Perrett,

    Affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    X
  • Youtao Song mail,

    ysong@lnu.edu.cn (YS); gary.jones@nuim.ie (GWJ)

    Affiliations: Province Key Laboratory of Animal Resource and Epidemic Disease Prevention, Liaoning University, Shenyang, China, School of Environmental Science, Liaoning University, Shenyang, China

    X
  • Gary W. Jones mail

    ysong@lnu.edu.cn (YS); gary.jones@nuim.ie (GWJ)

    Affiliation: Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland

    X
  • Published: January 31, 2013
  • DOI: 10.1371/journal.pcbi.1002896

About the Authors

Linan Xu, Jianwei He, Youlin Xue, Xiaohong Zhou, Youtao Song
Province Key Laboratory of Animal Resource and Epidemic Disease Prevention, Liaoning University, Shenyang, China
Naushaba Hasin, Gary W. Jones
Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
Manli Shen, Jianwei He, Youtao Song
School of Environmental Science, Liaoning University, Shenyang, China
Sarah Perrett
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LX YS GWJ. Performed the experiments: LX NH MS JH XZ. Analyzed the data: LX YX SP YS GWJ. Contributed reagents/materials/analysis tools: YS GWJ. Wrote the paper: LX SP YS GWJ.