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Research Article

Dynamic Modeling of Cell Migration and Spreading Behaviors on Fibronectin Coated Planar Substrates and Micropatterned Geometries

  • Min-Cheol Kim mail,

    mincheol@mit.edu

    Affiliations: BioSystem & Micromechanics IRG, Singapore MIT Alliance Research Technology, Singapore, Departments of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Devin M. Neal,

    Affiliation: Departments of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Roger D. Kamm,

    Affiliations: BioSystem & Micromechanics IRG, Singapore MIT Alliance Research Technology, Singapore, Departments of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • H. Harry Asada

    Affiliations: BioSystem & Micromechanics IRG, Singapore MIT Alliance Research Technology, Singapore, Departments of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pcbi.1002926

About the Authors

Min-Cheol Kim, Roger D. Kamm, H. Harry Asada
BioSystem & Micromechanics IRG, Singapore MIT Alliance Research Technology, Singapore
Min-Cheol Kim, Devin M. Neal, Roger D. Kamm, H. Harry Asada
Departments of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Roger D. Kamm
Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: mincheol@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: MCK DMN RDK HHA. Wrote the paper: MCK DMN RDK HHA. Built a code for the model: MCK. Performed the simulations: MCK DMN. Conceived and designed the experiments: MCK DMN RDK HHA.