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Research Article

Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the Blastema

  • Ron Stewart mail,

    rstewart@morgridgeinstitute.org

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Cynthia Alexander Rascón,

    Affiliation: Technical University Dresden, DFG Center for Regenerative Therapies Dresden, Fetscherstrasse 105 01039 Dresden, Germany

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  • Shulan Tian,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Jeff Nie,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Chris Barry,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Li-Fang Chu,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Hamisha Ardalani,

    Affiliation: Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Ryan J. Wagner,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Mitchell D. Probasco,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Jennifer M. Bolin,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Ning Leng,

    Affiliation: Department of Statistics, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Srikumar Sengupta,

    Affiliation: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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  • Michael Volkmer,

    Affiliation: Max-Planck-Institute for Biology of Ageing, Cologne, Germany

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  • Bianca Habermann,

    Affiliation: Max-Planck-Institute for Biology of Ageing, Cologne, Germany

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  • Elly M. Tanaka,

    Affiliation: Technical University Dresden, DFG Center for Regenerative Therapies Dresden, Fetscherstrasse 105 01039 Dresden, Germany

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  • James A. Thomson,

    Affiliations: Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America, Department of Cell & Regenerative Biology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Molecular, Cellular, & Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

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  • Colin N. Dewey

    Affiliation: Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Published: March 07, 2013
  • DOI: 10.1371/journal.pcbi.1002936

About the Authors

Ron Stewart, Shulan Tian, Jeff Nie, Chris Barry, Li-Fang Chu, Ryan J. Wagner, Mitchell D. Probasco, Jennifer M. Bolin, Srikumar Sengupta, James A. Thomson
Regenerative Biology, Morgridge Institute for Research, Madison, Wisconsin, United States of America
Cynthia Alexander Rascón, Elly M. Tanaka
Technical University Dresden, DFG Center for Regenerative Therapies Dresden, Fetscherstrasse 105 01039 Dresden, Germany
Hamisha Ardalani
Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, United States of America
Ning Leng
Department of Statistics, University of Wisconsin, Madison, Wisconsin, United States of America
Michael Volkmer, Bianca Habermann
Max-Planck-Institute for Biology of Ageing, Cologne, Germany
James A. Thomson
Department of Cell & Regenerative Biology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
James A. Thomson
Department of Molecular, Cellular, & Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America
Colin N. Dewey
Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Corresponding Author

Email: rstewart@morgridgeinstitute.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS CB LC JAT CND. Performed the experiments: CB LC HA RJW MDP JMB SS. Analyzed the data: RS CAR ST JN NL MV BH EMT CND. Contributed reagents/materials/analysis tools: EMT. Wrote the paper: RS CND.