Combined Model of Intrinsic and Extrinsic Variability for Computational Network Design with Application to Synthetic Biology

Tina Toni; Bruce Tidor

doi:10.1371/journal.pcbi.1002960

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Open Access

Peer-reviewed

Research Article

Combined Model of Intrinsic and Extrinsic Variability for Computational Network Design with Application to Synthetic Biology

Tina Toni ,

* E-mail: ttoni@mit.edu (TT); tidor@mit.edu (BT)

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Bruce Tidor

* E-mail: ttoni@mit.edu (TT); tidor@mit.edu (BT)

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Combined Model of Intrinsic and Extrinsic Variability for Computational Network Design with Application to Synthetic Biology

Tina Toni,
Bruce Tidor

Published: March 28, 2013
https://doi.org/10.1371/journal.pcbi.1002960

About the Authors

Tina Toni

* E-mail: ttoni@mit.edu (TT); tidor@mit.edu (BT)

Bruce Tidor

* E-mail: ttoni@mit.edu (TT); tidor@mit.edu (BT)

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TT BT. Performed the experiments: TT. Analyzed the data: TT BT. Contributed reagents/materials/analysis tools: TT. Wrote the paper: TT BT.

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Covariance
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Messenger RNA
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MicroRNAs
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Ellipses
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Biochemical simulations
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DNA-binding proteins
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Synthetic genetic networks
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Transcriptional control
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