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Research Article

Computational Biomarker Pipeline from Discovery to Clinical Implementation: Plasma Proteomic Biomarkers for Cardiac Transplantation

  • Gabriela V. Cohen Freue,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Anna Meredith,

    Affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Derek Smith,

    Affiliation: University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada

    X
  • Axel Bergman,

    Affiliation: Immunity and Infection Research Centre, Vancouver, British Columbia, Canada

    X
  • Mayu Sasaki,

    Affiliation: Immunity and Infection Research Centre, Vancouver, British Columbia, Canada

    X
  • Karen K. Y. Lam,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Zsuzsanna Hollander,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Nina Opushneva,

    Affiliation: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

    X
  • Mandeep Takhar,

    Affiliation: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

    X
  • David Lin,

    Affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Janet Wilson-McManus,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Robert Balshaw,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Paul A. Keown,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada, Immunology Laboratory, Vancouver General Hospital, Vancouver, British Columbia, Canada

    X
  • Christoph H. Borchers,

    Affiliation: University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada

    X
  • Bruce McManus,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, UBC James Hogg Research Centre, Vancouver, British Columbia, Canada

    X
  • Raymond T. Ng mail,

    rmcmaster@exchange.ubc.ca

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Computer Science, University of British Columbia, Vancouver, British Columbia, Canada

    RTN and WRM are joint senior authors on this work.

    X
  • W. Robert McMaster ,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Immunity and Infection Research Centre, Vancouver, British Columbia, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

    RTN and WRM are joint senior authors on this work.

    X
  • for the Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams

    Affiliation: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

    X
  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1002963

About the Authors

Gabriela V. Cohen Freue, Karen K. Y. Lam, Zsuzsanna Hollander, Nina Opushneva, Mandeep Takhar, Janet Wilson-McManus, Robert Balshaw, Paul A. Keown, Bruce McManus, Raymond T. Ng, W. Robert McMaster, for the Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams
NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada
Gabriela V. Cohen Freue, Robert Balshaw
Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada
Anna Meredith, Zsuzsanna Hollander, David Lin, Janet Wilson-McManus, Paul A. Keown, Bruce McManus
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Derek Smith, Christoph H. Borchers
University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada
Axel Bergman, Mayu Sasaki, W. Robert McMaster
Immunity and Infection Research Centre, Vancouver, British Columbia, Canada
Karen K. Y. Lam, Paul A. Keown
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Paul A. Keown
Immunology Laboratory, Vancouver General Hospital, Vancouver, British Columbia, Canada
Bruce McManus
UBC James Hogg Research Centre, Vancouver, British Columbia, Canada
Raymond T. Ng
Department of Computer Science, University of British Columbia, Vancouver, British Columbia, Canada
W. Robert McMaster
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: rmcmaster@exchange.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GVCF DS AB MS JWM RB PAK BM RTN WRM. Performed the experiments: DS AB MS PAK CHB BM WRM. Analyzed the data: GVCF AM ZH NO MT DL RB RTN. Contributed reagents/materials/analysis tools: GVCF DS AB MS JWM CHB WRM. Wrote the paper: GVCF AM KKYL BM RTN WRM.