About the Authors

Nisha Rajagopal

Affiliations Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, United States of America, Bioinformatics and Systems Biology program, University of California at San Diego, La Jolla, California, United States of America

Wei Xie

Affiliation Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, United States of America

Yan Li

Affiliation Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, United States of America

Uli Wagner

Affiliation Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, United States of America

Wei Wang

Affiliation Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, United States of America

John Stamatoyannopoulos

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Jason Ernst

Affiliations Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Manolis Kellis

Affiliation Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Bing Ren

biren@ucsd.edu

Affiliations Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, United States of America, Bioinformatics and Systems Biology program, University of California at San Diego, La Jolla, California, United States of America, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, and Moores Cancer Center, University of California at San Diego, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Discussion on algorithm development: JE MK BR. Advice on computational validations: WW. Overall guidance: BR. Conceived and designed the experiments: WX JS. Performed the experiments: YL. Analyzed the data: NR UW. Wrote the paper: NR.